Spontaneous Inhibitory Synaptic Currents Mediated by a G Protein-Coupled Receptor

نویسندگان

  • Stephanie C. Gantz
  • James R. Bunzow
  • John T. Williams
چکیده

G protein-coupled receptors (GPCRs) affect many physiological processes by modulating both intrinsic membrane conductances and synaptic transmission. This study describes spontaneous miniature inhibitory postsynaptic currents mediated by vesicular dopamine release acting locally on metabotropic D2 receptors leading to the activation of a G protein-coupled inwardly rectifying potassium conductance. Thus, individual exocytotic events result in spontaneous GPCR-mediated transmission, similar to synaptic activation of classical ligand-gated ion channels.

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عنوان ژورنال:
  • Neuron

دوره 78  شماره 

صفحات  -

تاریخ انتشار 2013